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ALOX15 KD normalized the intracellular GSH ( P = 0.003), while chemical inhibition of 15LO1 had a marginal, but insignificant effect ( P = 0.066)

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Senescent cells, through the secretion of SASP factors into their environment, influence neighboring non-senescent cells and the extracellular matrix (ECM), leading to inflammation, fibrosis, and programmed death of healthy cells, while simultaneously becoming resistant to apoptosis [34]

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